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RB Leipzig finished third after a 2-1 defeat at home to the group-winners Besiktas.
Elsewhere, Cristiano Ronaldo became the first player to score in all six of his side's group games as Real Madrid beat Borussia Dortmund 3-2.
Liverpool, Sevilla, Shakhtar and Porto all confirmed their places in the last 16 of the Champions League on Wednesday night, in the last round of games in the group stage, while Dortmund qualified for the Europa League, despite a defeat away to Real Madrid to end the opening phase without a win. It needed to win and hope Shakhtar lost to go through, and it seemed on course when Piotr Zielinksi put the Serie A power into a fourth-minute lead.
But Nicolai Jorgensen had headed Feyenoord level before halftime, and Jerry St. It didn't wind up mattering, because Shakhtar won anyway.
Sevilla finished second after a 1-1 draw at Maribor.
Salah and substitute Daniel Sturridge combined to tee up Mane for a sixth, and sharp footwork led to Salah lashing in the seventh.